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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
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Infectious complications and vaccines.
1Division of Hematology, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden; and Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Hematology. American Society of Hematology. Education Program
|December 10, 2021
Summary
Infections pose a significant risk to patients undergoing allogeneic hematopoietic cell transplantation. Enhancing vaccination and antimicrobial prophylaxis strategies is crucial for improving long-term survival rates.
Area of Science:
- Hematology
- Infectious Diseases
- Immunology
Background:
- Allogeneic hematopoietic cell transplantation (HCT) survivors face substantial risks of infection, impacting morbidity and mortality.
- Chronic graft-versus-host disease and delayed immune reconstitution are key risk factors for post-transplant infections.
Observation:
- Vaccination against pathogens like pneumococci, influenza, varicella-zoster virus, and SARS-CoV-2 is recommended for HCT survivors.
- Despite established recommendations for decades, the implementation of these crucial preventive strategies has been suboptimal.
Findings:
- Poor adherence to recommended vaccination schedules and antimicrobial prophylaxis regimens is a significant concern.
- Targeted strategies are necessary to address individual patient needs and improve infection prevention.
Implications:
- Improving the uptake of vaccinations and antimicrobial prophylaxis can reduce infection-related complications and mortality in HCT survivors.
- Further research and clinical interventions are needed to enhance the implementation of evidence-based infection prevention guidelines.
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