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Updated: Aug 10, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry
Published on: October 8, 2012
Anti-Thy-1 response of H-2f/H-2r heterozygotes: an unusual case of genetic control
Abstract:
Anti-Thy-1 responsiveness of H-2r homozygous and H-2f/H-2r heterozygous mice was studied. Good responsiveness appeared to be independent of H-2 phenotype of responder but was influenced by the phenotype of the donor. These results were incompatible with the concept of Ir-Thy-1 genes controlling the response to cell-free Thy-1 in these mice. In contrast the results were indicative of the response to the cell-bound form of the Thy-1 antigen. It is proposed that good anti-Thy-1 response may reflect the presence of clones capable of recognizing the Thy-1 antigen in the context of or in association with incompatible class I H-2 molecules.
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