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Injectable Micromotor@Hydrogel System for Antibacterial Therapy.

Sicheng Yang1, Jiaoyu Ren1, Hong Wang1

  • 1School of Chemical Engineering & Technology, China University of Mining and Technology, No. 1, Daxue Road, Xuzhou, Jiangsu, 221116, P. R. China.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|December 10, 2021
PubMed
Summary

This study introduces an injectable micromotor@hydrogel system for drug delivery. This novel system protects micromotors in biological environments, enhancing drug release and antibacterial efficacy against infections.

Keywords:
antibacterial activitydrug deliveryhydrogelmicromotors

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Micromotors show promise for drug delivery but face challenges in biological environments, including potential damage and premature drug leakage.
  • Protecting micromotors is crucial for maintaining their structural integrity and propulsion efficiency in vivo.

Purpose of the Study:

  • To develop an injectable micromotor@hydrogel drug delivery system to safeguard micromotors.
  • To enhance the stability and sustained-release properties of micromotors in complex biological settings.
  • To evaluate the antibacterial efficacy of the developed system.

Main Methods:

  • Micromotors were fabricated using layer-by-layer assembly with platinum nanoparticles for propulsion via hydrogen peroxide decomposition.
  • Micromotors were encapsulated within a Schiff base hydrogel to form the micromotor@hydrogel system.
  • The system was loaded with erythromycin (Ery) and its antibacterial activity was assessed in vitro.

Main Results:

  • The micromotor@hydrogel system demonstrated efficient propulsion and protected micromotors from environmental degradation.
  • Sustained release of erythromycin was observed, leading to a significant antibacterial effect.
  • Micromotors released from the hydrogel exhibited enhanced diffusion around bacteria, even without external hydrogen peroxide.

Conclusions:

  • The injectable micromotor@hydrogel system provides a protective and stable platform for drug delivery.
  • This novel strategy offers improved therapeutic outcomes for bacterial infections by enhancing drug release and micromotor performance.
  • The system presents a promising new approach for advanced drug delivery applications in medicine.