Related Experiment Video

Updated: Oct 10, 2025

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

24.3K

Myocardial function reclassification: Echocardiographic strain patterns in patients with chronic Chagas

Guilherme A T Athayde1, Bruno C C Borges2, Andreia O Pinheiro1

  • 1Cardiac Stimulation Clinical Unit, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

International Journal of Cardiology
|December 10, 2021
PubMed

Insights

This study reclassified myocardial function in Chronic Chagas Cardiomyopathy (CCC) patients by analyzing global longitudinal strain (GLS) and intraventricular dyssynchrony (IVD) during rest and exercise, identifying subgroups with contractile reserve.

Area of Science:

  • Cardiology
  • Echocardiography
  • Myocardial mechanics

Background:

  • Chronic Chagas Cardiomyopathy (CCC) patients with left ventricular dysfunction (LVD) and non-left bundle branch block (non-LBBB) exhibit varied functional and mechanical patterns.
  • Identifying distinct subgroups based on global longitudinal strain (GLS) and intraventricular dyssynchrony (IVD) is crucial for understanding CCC progression.

Purpose of the Study:

  • To identify subgroups of CCC patients with LVD and non-LBBB based on distinct GLS and IVD patterns at rest and during exercise.
  • To reclassify myocardial function in these patients using a novel echocardiographic approach.

Main Methods:

  • A single-center cross-sectional study involving 40 CCC patients with LVEF ≤ 35% and non-LBBB.
  • Rest and treadmill exercise stress echocardiography were performed, analyzing GLS and IVD.
  • Patients were categorized into four groups based on GLS and IVD variations between rest and exercise.

Main Results:

  • No significant differences in baseline LVEF or GLS were observed among the four groups.
  • The GLS-IVD+ group showed greater resting dyssynchrony (p=0.01).
  • Significant differences in baseline left atrial volume and TAPSE were noted between groups. 67.5% of patients had very severe LVD, and 11 showed contractile reserve.

Conclusions:

  • Echocardiographic evaluation of GLS and IVD during rest and exercise effectively reclassifies myocardial function in CCC patients.
  • This approach identifies subgroups with contractile reserve and significant dyssynchronopathy, aiding in personalized treatment strategies.
Abstract

Keywords:
Chagas cardiomyopathyIntraventricular dyssynchronyStress echocardiographyVentricular dysfunction

More Related Videos

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

16.3K
Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.5K

Related Concept Videos

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
118
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
86
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
60
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
93
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
73
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
61