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2019 Global NAFLD Prevalence: A Systematic Review and Meta-analysis
Michael H Le1, Yee Hui Yeo2, Xiaohe Li3
1Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, California.
The global prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing, now affecting nearly 30% of people worldwide. Urgent public health interventions are needed to address this growing trend.
Area of Science:
- Hepatology and Gastroenterology
- Public Health and Epidemiology
Background:
- Rising rates of obesity and type 2 diabetes mellitus are linked to increased nonalcoholic fatty liver disease (NAFLD) prevalence.
- NAFLD is a growing global health concern, necessitating an understanding of its current prevalence and trends.
Approach:
- A systematic literature search was conducted up to March 2020, identifying 245 studies with over 5.3 million participants.
- Meta-regression analysis was employed to determine global and regional trends in NAFLD prevalence.
Key Points:
- The global pooled prevalence of NAFLD is 29.8%, with significant regional variations.
- South America and North America exhibit the highest NAFLD prevalence rates.
- NAFLD prevalence has steadily increased from 21.9% in 1991 to 37.3% in 2019.
Conclusions:
- The global prevalence of NAFLD is on the rise, demanding immediate attention.
- Policy interventions focusing on increased awareness and promotion of healthy lifestyles are crucial to reverse current trends.
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