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Mitochondria determine response to anti-programmed cell death protein-1 (anti-PD-1) immunotherapy: An evidence-based

Hassan Akbari1, Farzad Taghizadeh-Hesary2, Moslem Bahadori3

  • 1Department of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Traditional Medicine School, Tehran University of Medical Sciences, Tehran, Iran.

Mitochondrion
|December 10, 2021
PubMed

Insights

Cellular adenosine triphosphate (ATP) levels predict response to cancer immunotherapy. Low ATP impairs T cell function, highlighting mitochondria

Area of Science:

  • Oncology
  • Immunology
  • Cellular Biology

Background:

  • Programmed cell death protein-1 (PD-1) immunotherapy shows promise in cancer treatment.
  • A significant number of patients do not respond to PD-1 blockade therapy.
  • Identifying predictive factors for PD-1 blockade response is crucial.

Purpose of the Study:

  • To provide an overview of potential predictive factors for PD-1 blockade therapy.
  • To emphasize the role of mitochondria in anti-PD-1 therapy response.

Main Methods:

  • Literature review of predictive factors for PD-1 blockade.
  • Analysis of the role of cellular adenosine triphosphate (c-ATP) in T cell function.
  • Examination of mitochondrial involvement in immunotherapy response.

Main Results:

  • Decreased cellular adenosine triphosphate (c-ATP) levels are linked to cellular dysfunction.
  • ATP is essential for T cell migration and activation.
  • Reduced c-ATP impairs T cell function and may promote cancer progression.

Conclusions:

  • Cellular adenosine triphosphate (c-ATP) levels may serve as a predictive factor for PD-1 blockade efficacy.
  • Mitochondrial function is critical for effective anti-PD-1 therapy.
  • Further research into c-ATP and mitochondria could improve patient selection for immunotherapy.
Keywords:
Adenosine triphosphateMitochondriaProgrammed cell death protein-1T cell

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