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Related Experiment Video

Updated: Oct 10, 2025

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
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Human dental pulp stem cells and hormesis.

Edward J Calabrese1, Evgenios Agathokleous2, Gaurav Dhawan3

  • 1Department of Environmental Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA 01003, USA.

Ageing Research Reviews
|December 10, 2021
PubMed
Summary
This summary is machine-generated.

This study reveals that human dental pulp stem cells (hDPSCs) exhibit hormetic dose responses to various chemicals, impacting cell renewal and differentiation. These findings have implications for understanding stem cell behavior and potential therapeutic applications.

Keywords:
Biphasic dose responseCell differentiationCell proliferationDental pulp stem cellsHormesisStem cell

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Area of Science:

  • Stem cell biology
  • Pharmacology
  • Toxicology

Background:

  • Hormesis, a dose-response phenomenon, is increasingly recognized across biological systems.
  • Human dental pulp stem cells (hDPSCs) are a promising cell source for regenerative medicine.
  • Understanding hDPSCs' responses to chemical stimuli is crucial for their therapeutic application.

Purpose of the Study:

  • To investigate hormetic dose responses in hDPSCs.
  • To examine the effects of various chemicals on hDPSCs' proliferation and differentiation.
  • To explore the mechanistic basis and therapeutic potential of hDPSCs' hormetic responses.

Main Methods:

  • Exposure of hDPSCs to a range of chemicals, including pharmaceuticals, plant extracts, and endogenous agents.
  • Assessment of cell proliferation and differentiation markers.
  • Analysis of dose-response curves to identify hormetic patterns.

Main Results:

  • Hormetic dose responses were frequently observed in hDPSCs across diverse chemical treatments.
  • Tested compounds included metformin, artemisinin, berberine, N-acetyl-L-cysteine, ginsenoside Rg1, ATP, and TNF-α.
  • The study identified mechanistic foundations for these hormetic responses in both proliferation and differentiation.

Conclusions:

  • hDPSCs exhibit robust hormetic dose responses to a wide array of chemical agents.
  • These findings highlight the complexity of stem cell behavior and chemical interactions.
  • Understanding hormesis in hDPSCs may lead to novel therapeutic strategies in regenerative medicine.