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Pharmacomechanical catheter-directed thrombolysis for acute iliofemoral deep vein thrombosis in a large study

Ali Baran Budak1, Orhan Eren Gunertem2, Kanat Ozisik3

  • 1Department of Cardiovascular Surgery, Alanya Practice and Research Center, Başkent University Faculty of Medicine, Antalya, Turkey.

Journal of Vascular Surgery. Venous and Lymphatic Disorders
|December 10, 2021
PubMed

Insights

Pharmacomechanical catheter-directed thrombolysis (PMCDT) effectively treats acute iliofemoral deep vein thrombosis (IFDVT), reducing symptoms and preventing post-thrombotic syndrome (PTS). This minimally invasive approach improves quality of life for eligible patients.

Area of Science:

  • Vascular Surgery
  • Interventional Radiology
  • Cardiovascular Medicine

Background:

  • Acute iliofemoral deep vein thrombosis (IFDVT) poses significant risks, including post-thrombotic syndrome (PTS).
  • Pharmacomechanical catheter-directed thrombolysis (PMCDT) is an emerging treatment option for IFDVT.

Purpose of the Study:

  • To evaluate the safety, accuracy, and efficacy of PMCDT in managing acute IFDVT.
  • To assess the impact of PMCDT on quality of life and prevention of PTS.

Main Methods:

  • Retrospective review of 230 patients undergoing PMCDT for IFDVT from January 2017 to December 2018.
  • Analysis of preoperative, operative, and postoperative variables, Marder scores, and follow-up assessments using Villalta and venous clinical severity scores.

Main Results:

  • Anatomical success was achieved in 95.2% of patients, with significant reduction in Marder scores (12.65 to 2.4).
  • Primary patency rates were high (94.0% at 1 month, 81.7% at 12 months).
  • Significant improvements in Villalta and venous clinical severity scores were observed, indicating reduced PTS severity and improved quality of life.

Conclusions:

  • PMCDT is a safe and effective treatment for acute IFDVT, leading to significant symptom reduction.
  • PMCDT, combined with anticoagulation, helps prevent PTS and improves patient quality of life.
Abstract

Keywords:
Acute iliofemoral deep vein thrombosisPharmacomechanical catheter-directed thrombolysisPost-thrombotic syndrome

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