An Optimal Strategy for Individualized Drug Delivery Therapy: A Molecular Communication Inspired Waveform Design...

To enhance the drug delivery therapy efficacy and reduce the adverse effects on patients, we propose a molecular communication (MC) inspired optimization strategy to maintain the locoregional concentration of drug within a therapeutic window, the safe drug concentration range for individualized therapy. Observing the parallels between the propagation of information molecules and the delivery of drugs, MC, as a new paradigm, has drawn devised to overcome the challenges of the drug delivery system. The drug delivery is mapping to the transmission process of information molecules from the transmitter to the receiver. In addition, the locoregional concentration-time profile of the administered drug particles corresponds to the signalling waveform. Different from conventional drug delivery strategy, this work focuses on locoregional concentration instead of plasma concentration. Furthermore, with sustained-release preparations schemes, we also propose an algorithm to obtain the optimal administration time. The simulation results demonstrate that this strategy effectively maintains the relative steady-state drug concentration.