Iterative method to obtain semi-circle variables from bioimpedance measurements for Cole's Modeling

Bioimpedance Spectroscopy measurements and Cole-Cole models are commonly used to characterize biological systems. Cole-Cole model parameters may be obtained by fitting the measured bioimpedance data into a semicircle. This work proposes an iterative method to approximate a bioimpedance dataset to a Cole-Cole model analysis using only three points. The performance of the proposed method was compared against similar methods reported in a recent publication; our proposal presents greater efficiency (87.5%) and lower mean error (0.022) than the compared methods. The main contribution of the proposed method is that its performance does not rely on the user's technical knowledge, neither does it on the instrument used to perform the measurements, while the compared methods do.Clinical Relevance- Our proposal is an efficient unsupervised iterative method to acquire the clinically-relevant parameters from a Cole-Cole analysis from a given bioimpedance spectroscopy dataset, eliminating the need for the user to have prior technical knowledge on bioimpedance, thus, furthering the use of bioimpedance technology in the clinical point-of-care.