The Imaging of Magnetic Nanoparticles with Low-power Magnetoacoustic Tomography

The magnetic nanoparticles have been widely explored as an important kind of biomaterial for the treatment and diagnosis of cancer. Imaging of magnetic nanoparticles can greatly facilitate treatment and diagnosis in both preclinical and clinical applications. The magnetoacoustic tomography is a non-invasive imaging modality for the distribution of the magnetic nanoparticles. However, the traditional magnetoacoustic imaging system requires higher power and the large instantaneous current that suffers cost and safety issues. In this paper, we propose a low-power magnetoacoustic tomography system, whose power amplifier only has 30 W peak power. The system used a pulse train of excitation to gain energy accumulation by resonance. The reconstructed algorithm, i.e. universal back-projection, was applied for imaging. To prove the feasibility and potential of the proposed system, we performed the imaging experiments with the gelatin phantom containing the magnetic nanoparticles.