High-Framerate A-Mode Ultrasound for Vascular Structural Assessments: In-Vivo Validation in a Porcine Model

Capturing vascular dynamics using ultrasound at a high framerate provided a unique way to track time-dependent and transient physiologic events non-invasively. In this work, we present an A-model high-framerate (500 frames per second) image-free ultrasound system for monitoring vascular structural and material properties. It was developed based on our clinically validated ARTSENS^® technology. Following in-vitro verification on arterial flow phantoms, its measurement accuracy and high-framerate data acquisition and processing were verified in-vivo on 2 anesthetized Sus scrofa swine. Measurements of the carotid artery (the luminal diameter, distension, and wall thickness) obtained using the high-framerate system were comparable to those provided by a clinical-grade reference ultrasound imaging device (absolute error < 4%, < 6.3%, and < 6.6%, respectively). Notably, the morphology of the arterial distension waveforms obtained at high-framerate depicted vital physiological fiduciary points compared to the low-framerate reference waveform. The compression-decompression pattern of the arterial wall was also captured with the high-framerate system, which is challenging with low-framerate ultrasound. Potential applications of these high temporal structural waveforms have also been discussed.