Laser Power Determination Using Light-to-Heat Conversion Rate of Nanoplasmonic Substrates for Neural Stimulation

Since neurons have temperature sensitive properties, gold nanorod (GNR)-mediated photothermal stimulation has been developed as a neuromodulation application. As an in vitro photothermal platform, GNR-layer was integrated with substrates to effectively apply heat stimulation to the cultured neurons. However, identifying optimal laser power for a targeted temperature on the substrate requires the consideration of thermal properties of the GNR-coated substrates. In this report, we suggest a simple numerical method to determine incident laser power on the substrates for a targeted temperature.