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Updated: Oct 10, 2025

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

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Lipoprotein(a) and aortic valve stenosis: A casual or causal association?

Gloria Santangelo1, Andrea Faggiano2, Nicola Bernardi3

  • 1Division of Cardiology, San Paolo Hospital, Department of Health Sciences, University of Milan, Italy.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|December 11, 2021
PubMed

Insights

This review updates imaging methods for aortic valve calcification activity and discusses therapeutic options. Current treatments focus on valve replacement, as medical therapies for aortic stenosis remain unproven.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Pharmacology

Background:

  • Aortic valve calcification is a prevalent heart valve condition in adults, often necessitating intervention.
  • Current medical therapies do not effectively manage symptoms or slow the progression of aortic valve calcification.
  • Aortic valve replacement (surgical or transcatheter) is the sole established treatment for aortic valve calcification.
  • Elevated lipoprotein(a) levels are strongly linked to degenerative aortic stenosis, with causal evidence from genetic studies.

Purpose of the Study:

  • To provide an updated overview of imaging techniques for assessing calcification activity in aortic valve stenosis.
  • To review potential therapeutic strategies for managing aortic valve calcification.
  • To highlight emerging therapeutic targets and imaging modalities for aortic valve stenosis.

Main Methods:

  • Literature review of available imaging methods for calcification activity.
  • Analysis of current and emerging therapeutic options for aortic valve calcification.
  • Synthesis of evidence linking lipoprotein(a) to aortic stenosis pathophysiology.

Main Results:

  • Established imaging techniques for evaluating calcification activity are discussed.
  • The limitations of current medical therapies for aortic valve calcification are highlighted.
  • The strong association between lipoprotein(a) and aortic stenosis is confirmed.

Conclusions:

  • New therapeutic targets for aortic valve stenosis are emerging.
  • Advanced imaging techniques may be crucial for evaluating novel therapeutic agents.
  • Further research is needed to clarify the pathophysiology of aortic valve stenosis and develop effective Lp(a)-lowering therapies.
Abstract

Keywords:
Aortic valve calcificationAortic valve stenosisDrug therapyLipoprotein (a)

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