Related Experiment Video

Updated: Oct 10, 2025

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
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A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

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Prostate-specific membrane antigen positron emission tomography compared to multiparametric MRI for prostate cancer

Yi Zhao1, Naomi Morka2, Benjamin Scott S Simpson3

  • 1Imperial College London, London, UK yi.zhao18@imperial.ac.uk.

BMJ Open
|December 11, 2021
PubMed
Abstract

Insights

This systematic review protocol compares multiparametric MRI (mpMRI) and prostate-specific membrane antigen positron emission tomography (PSMA PET) for diagnosing prostate cancer. It aims to determine which imaging technique offers superior accuracy in detecting and staging the disease.

Area of Science:

  • Urology
  • Radiology
  • Oncology

Background:

  • Multiparametric MRI (mpMRI) has enhanced prostate cancer diagnosis.
  • Prostate-specific membrane antigen positron emission tomography (PSMA PET) shows promise for improved accuracy.
  • Direct comparison of mpMRI and PSMA PET in diagnosis is needed.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis comparing mpMRI and PSMA PET.
  • To evaluate the diagnostic accuracy of both imaging modalities for suspected prostate cancer.
  • To determine the optimal imaging technique for prostate cancer detection and staging.

Main Methods:

  • Systematic literature search of MEDLINE, EMBASE, PubMed, and Cochrane databases.
  • Adherence to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
  • Inclusion of full-text English articles comparing PSMA PET and mpMRI published between July 1977 and March 2021; quality assessed using Quadas-2.

Main Results:

  • This section will report the findings of the meta-analysis comparing diagnostic accuracy metrics.
  • Results will quantify the performance of mpMRI versus PSMA PET in detecting and staging prostate cancer.
  • Bias and quality assessment of included studies will be presented.

Conclusions:

  • The study will conclude on the comparative diagnostic accuracy of PSMA PET and mpMRI for prostate cancer.
  • Findings will inform clinical practice regarding the preferred imaging modality.
  • Dissemination via peer-reviewed publications and conference presentations.
Keywords:
MRIprostate diseaseurological tumours

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