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Related Experiment Video

Updated: Oct 10, 2025

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

Published on: March 22, 2016

Memory Trajectories Before and After First and Recurrent Strokes.

Wentian Lu¹, Marcus Richards², David Werring²

¹From the Research Department of Epidemiology and Public Health (W.L., M.B.), MRC Unit for Lifelong Health & Ageing (M.R.), and Stroke Research Centre, UCL Queen Square Institute of Neurology (D.W.), University College London, UK. wentian.lu.14@ucl.ac.uk.

|December 11, 2021

Summary

This summary is machine-generated.

Stroke causes acute memory loss, with recurrent strokes having a greater impact. Better acute stroke care, like endovascular treatment, may reduce memory decline after a stroke.

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Area of Science:

Neurology
Gerontology
Public Health

Background:

Limited evidence exists on memory changes following first and recurrent strokes.
Investigating memory trajectories across diverse European populations is crucial.

Purpose of the Study:

To examine memory changes before and after first and recurrent strokes.
To assess the association between country-level acute stroke care and post-stroke memory changes.

Main Methods:

Utilized data from the Survey of Health, Ageing and Retirement in Europe (2004-2019).
Employed propensity score matching to create case (stroke) and control (stroke-free) groups.
Applied multilevel segmented linear regression to analyze memory changes (word recall scores).

Main Results:

Participants experienced acute memory score decreases of 0.48 words after first stroke and 1.14 words after recurrent stroke.
Memory decline rates over time were similar in stroke and control groups (-0.07 vs -0.06 words/year).
Countries with better access to endovascular treatment showed smaller acute memory decreases post-stroke.

Conclusions:

Acute memory decrements, not accelerated declines, were observed post-stroke.
Enhanced endovascular therapy may mitigate memory loss, warranting further individual-level data research.
Prioritizing early stroke assessment, prevention, and acute care access is essential for the aging population.