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Updated: Oct 10, 2025
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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The emerging association between bronchiectasis and systemic sclerosis: assessing prevalence and potential causality.
Rosemary Smith1, Megan Harrison2,3, Kay-Vin Lam4
1Department of General Medicine, Fiona Stanley Hospital, Perth, Western Australia, Australia.
Internal Medicine Journal
|December 11, 2021
Summary
Systemic sclerosis (SSc) patients show increased bronchiectasis risk, but not linked to disease duration. Oesophageal dysmotility was common, and bronchiectasis showed a negative association with interstitial lung disease (ILD).
Area of Science:
- Pulmonary Medicine
- Rheumatology
- Radiology
Background:
- Bronchiectasis is observed in systemic sclerosis (SSc).
- Potential causes include aspiration from oesophageal dysmotility, immunosuppressant use, and direct collagen deposition affecting airways.
Purpose of the Study:
- To determine bronchiectasis prevalence in SSc patients using high-resolution computed tomography (HRCT).
- To investigate associations between bronchiectasis and oesophageal dysmotility, demographics, SSc duration, or subclass.
Main Methods:
- Included 256 SSc patients from the Australian Scleroderma Cohort Study (ASCS) with thoracic HRCT.
- Reviewed HRCT for bronchiectasis and interstitial lung disease (ILD).
- Defined oesophageal dysmotility by symptoms and/or dilatation.
Main Results:
- 16.4% of participants had bronchiectasis.
- No significant association found between bronchiectasis and oesophageal dysmotility, demographics, or SSc duration/subclass.
- A negative association was observed between bronchiectasis and ILD (P=0.009).
Conclusions:
- SSc patients have an elevated risk of bronchiectasis.
- Bronchiectasis development may not solely relate to immunosuppression, given no link to SSc duration.
- Oesophageal dysmotility was nearly universal, precluding definitive conclusions on its role. Bronchiectasis and ILD were negatively associated.
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