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Optimized Dosing: The Next Step in Precision Medicine in Non-Small-Cell Lung Cancer

René J Boosman1, Jacobus A Burgers2, Egbert F Smit2

  • 1Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. r.boosman@nki.nl.

Drugs
|December 11, 2021
PubMed

Insights

Optimizing drug doses in non-small-cell lung cancer (NSCLC) treatment is crucial for precision medicine. Evidence suggests tailored dosing for small-molecule inhibitors, chemotherapy, and antibodies can improve outcomes and reduce healthcare costs.

Area of Science:

  • Oncology
  • Pharmacology
  • Precision Medicine

Background:

  • Dose optimization is often overlooked in non-small-cell lung cancer (NSCLC) treatment.
  • Current "one dose fits all" approaches lead to pharmacokinetic variability and suboptimal outcomes.
  • Advancements in pharmacology highlight the potential of strategies like therapeutic drug monitoring.

Purpose of the Study:

  • To review evidence for optimized dosing strategies in NSCLC treatment.
  • To focus on small-molecule inhibitors, chemotherapeutic agents, and monoclonal antibodies.
  • To provide recommendations for implementing dose optimization in NSCLC.

Main Methods:

  • Literature review of optimized dosing approaches for NSCLC treatments.
  • Analysis of evidence for small-molecule inhibitors, chemotherapeutic agents, and monoclonal antibodies.
  • Consideration of studies conducted in other oncological diseases and retrospective analyses.

Main Results:

  • Optimized dosing regimens show potential benefits for treatment outcomes.
  • Alternative dosing can enhance prescriber convenience and reduce financial burdens.
  • Despite limitations, optimized dosing strategies warrant further investigation and implementation.

Conclusions:

  • Implementing optimized dosing in NSCLC can significantly improve patient care and healthcare efficiency.
  • Further research is needed to validate and refine these strategies for broader application.
  • Dose optimization represents a vital component of precision medicine in NSCLC therapy.

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