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Related Concept Videos

Issues And Trends In Healthcare Delivery System01:29

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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Drug distribution within the body is a dynamic process involving the movement of a drug in two directions across various compartments: from the bloodstream into tissues (tissue uptake) and from tissues back into the bloodstream (tissue release or redistribution). This process is passive and primarily driven by two variables: the concentration gradient between the bloodstream and the extravascular tissues and the drug's ability to cross the cell membrane.
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Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
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The volume of distribution refers to the theoretical volume necessary to contain the entire amount of an administered drug at the same concentration observed in the blood plasma. The body's intracellular fluid compartment, which makes up two-thirds of the total body water, is contrasted with the extracellular fluid compartment—comprising plasma and interstitial fluid—that accounts for one-third. The volume of distribution can vary depending on the characteristics of the drug.
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Related Experiment Video

Updated: Oct 10, 2025

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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A robust drug recall supply chain management system using hyperledger blockchain ecosystem.

Divyansh Agrawal1, Sachin Minocha2, Suyel Namasudra3

  • 1School of Computing Science and Engineering, Galgotias University, Uttar Pradesh, India.

Computers in Biology and Medicine
|December 11, 2021
PubMed
Summary

This study introduces a blockchain system for secure pharmaceutical supply chains. It enhances drug traceability and reduces recall costs and time for manufacturers.

Keywords:
BlockchainHyperledger composerPharmaceutical industryProduct recallSupply chain

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Area of Science:

  • Pharmaceutical Supply Chain Management
  • Blockchain Technology Applications
  • Operations Research in Healthcare

Background:

  • Drug recalls pose significant risks to manufacturing companies, potentially leading to severe business repercussions and loss of life.
  • Ensuring drug safety and traceability throughout the supply chain is paramount in the pharmaceutical industry.
  • Current supply chain models may incur substantial costs and time delays, particularly during drug recalls.

Purpose of the Study:

  • To develop a blockchain-enabled network for enhanced security and transparency in pharmaceutical drug monitoring.
  • To propose mathematical models for optimizing the forward and backward supply chain processes.
  • To minimize the time and cost associated with drug delivery and recall procedures.

Main Methods:

  • Implementation of a blockchain-enabled network for real-time drug monitoring.
  • Development of forward and backward supply chain mathematical models.
  • Real-time system demonstration using Hyperledger Composer.

Main Results:

  • The proposed blockchain system enhances security and transparency in drug supply chain management.
  • Mathematical models effectively minimize time and cost for drug delivery and recall.
  • The Hyperledger Composer implementation validates the system's transparency and efficiency.

Conclusions:

  • Blockchain technology offers a robust solution for secure and transparent pharmaceutical supply chains.
  • Optimized supply chain models reduce operational costs and improve recall efficiency.
  • The integrated system provides a reliable framework for pharmaceutical product lifecycle management.