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Indirect costs associated with skin infectious disease in children: a systematic review

Irene Lizano-Díez1, Jesús Naharro2, Ilonka Zsolt2

  • 1Ferrer Internacional, S.A., Av Diagonal 549, 5th floor, 08029, Barcelona, Spain. ilizano@ferrer.com.

BMC Health Services Research
|December 13, 2021
PubMed

Insights

The indirect costs of pediatric skin and soft tissue infections (SSTIs) are significant but understudied. This review highlights the economic burden, emphasizing the need for more research on these common childhood infections.

Area of Science:

  • Pediatric Infectious Diseases
  • Health Economics
  • Public Health

Background:

  • Limited data exists on the indirect economic costs of skin and soft tissue infections (SSTIs) in children.
  • This study addresses the gap by systematically reviewing indirect costs associated with pediatric SSTIs.

Purpose of the Study:

  • To conduct a systematic review of the literature on indirect costs related to skin and soft tissue infections in the pediatric population.
  • To consolidate and analyze existing data on the economic impact of pediatric SSTIs.

Main Methods:

  • A systematic literature search was performed in PubMed, SCOPUS, and Web of Science up to January 2020.
  • Thirteen search strategies were employed, defining SSTIs broadly to include bacterial, viral, fungal, and parasitic infections.
  • Only primary studies were included, with all costs converted to 2020 Euros.

Main Results:

  • Thirteen publications reported indirect costs of pediatric SSTIs across nine countries.
  • Varicella-zoster virus infections incurred caregiver lost workdays (0.27-7.8 days) and productivity losses (€1.16-€257.46/patient).
  • Acute bacterial SSTIs (e.g., MRSA) resulted in higher productivity losses (€1,814.39-€8,224.06/patient), while parasitic infestations like head lice added €90/patient in costs.

Conclusions:

  • The economic burden of pediatric SSTIs is substantial and often underestimated due to a scarcity of indirect cost studies.
  • Further research quantifying these indirect costs is crucial for a comprehensive understanding of the disease's financial impact.
Abstract

Keywords:
ChildCost of illnessIndirect costsSSTIsSkin infectious diseasesSystematic review

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