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Blood purification could tackle COVID-19?

Hiroyuki Yamada1,2, Shigeru Ohtsuru3

  • 1Department of Primary Care and Emergency Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin-kawaharacho, Sakyo-ku, Kyoto, 6068507, Japan. hyamada@kuhp.kyoto-u.ac.jp.

Journal of Intensive Care
|December 13, 2021
PubMed

Insights

Severe COVID-19 treatment is challenging. Blood purification techniques, including plasma exchange and hemoperfusion, show promise in managing critical illness by targeting cytokines and coagulopathy.

Area of Science:

  • Critical Care Medicine
  • Nephrology
  • Infectious Diseases

Background:

  • The global impact of Coronavirus disease 2019 (COVID-19) necessitates advanced treatment strategies for severe cases.
  • Blood purification is a recognized modality for managing critical illnesses, offering theoretical benefits for COVID-19.
  • Key challenges in severe COVID-19 include managing cytokine storms and coagulopathy.

Discussion:

  • Therapeutic plasma exchange has demonstrated positive clinical outcomes in severe COVID-19 patients.
  • Other blood purification methods, such as Cytosorb, AN69 membranes, and polymyxin B hemoperfusion, show considerable potential.
  • These techniques may mitigate the systemic inflammatory response and correct coagulopathies associated with severe COVID-19.

Key Insights:

  • Blood purification offers a promising avenue for managing severe COVID-19.
  • Specific techniques like plasma exchange, Cytosorb, AN69, and polymyxin B hemoperfusion warrant further investigation.
  • Effective management of cytokines and coagulopathy is crucial for improving patient outcomes.

Outlook:

  • Further clinical research is essential to confirm the efficacy and optimal application of blood purification in COVID-19.
  • Standardization of blood purification protocols for COVID-19 may improve treatment effectiveness.
  • Exploring the synergistic effects of combined blood purification techniques could offer enhanced therapeutic benefits.

Keywords:
AN69STApheresisCoronavirusCytokineCytosorbOxirisPMX-DHPPandemicPlasma exchangePlasmapheresis

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