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The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2
Marieke Mb Hoekstra1, Maxime Jan1, Georgia Katsioudi1
1Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Elife
|December 13, 2021
Summary
The Period-2 (Per2) gene rhythm in mouse tissues is influenced by sleep patterns, not just the central circadian clock. This finding suggests Per2 integrates sleep needs with daily rhythms for adaptability.
Area of Science:
- Chronobiology
- Molecular Biology
- Sleep Science
Background:
- The circadian rhythm of Period-2 (Per2) gene expression in peripheral tissues is not fully understood.
- Existing research suggests a link between Per2 expression and sleep-wake cycles.
Purpose of the Study:
- To investigate the relationship between Per2 expression rhythms and sleep-wake states in mice.
- To determine if sleep-wake distribution directly influences peripheral Per2 rhythms.
Main Methods:
- Simultaneous recording of sleep-wake state and PER2 bioluminescence in freely behaving mice.
- Utilizing SCN-lesioned mice to assess the SCN-independent contribution to Per2 rhythmicity.
- Employing mathematical modeling to describe PER2 dynamics.
Main Results:
- PER2 bioluminescence was observed to increase during spontaneous waking and decrease during sleep.
- Daily sleep deprivation temporarily restored PER2 rhythmicity in behaviorally arrhythmic SCN-lesioned mice.
- Mathematical models indicated that Per2 dynamics are driven by both sleep-wake and SCN-independent circadian forces.
Conclusions:
- Peripheral Per2 rhythms are significantly influenced by sleep-wake states.
- The clock gene circuitry in peripheral tissues integrates sleep-wake information.
- This integration may enhance behavioral adaptability to meet homeostatic needs.
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