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Global estimates of paediatric tuberculosis incidence in 2013-19: a mathematical modelling analysis
Sita Yerramsetti1, Ted Cohen2, Rifat Atun1
1Department of Global Health and Population, Harvard T H Chan School of Public Health, Boston, MA, USA.
Insights
Global estimates reveal nearly one million childhood tuberculosis cases annually, with significant underreporting, especially in younger children. Improvements in diagnosis and reporting are crucial for reducing pediatric TB burden.
Area of Science:
- Global Health
- Epidemiology
- Infectious Diseases
Background:
- Tuberculosis (TB) diagnosis and reporting systems often miss pediatric cases.
- Accurate estimation of childhood TB incidence and underreporting is critical for public health interventions.
Purpose of the Study:
- To estimate pediatric tuberculosis incidence and underreporting globally between 2013 and 2019.
- To analyze trends in case detection ratios (CDR) for children aged 0-4 and 5-14 years.
Main Methods:
- Developed a mathematical model of pediatric TB natural history, incorporating risk factors like HIV, malnutrition, and BCG non-vaccination.
- Utilized UN population data and WHO adult TB incidence rates, parameterizing the model for 185 countries.
- Calibrated the model using data from countries with robust reporting systems to estimate pediatric TB incidence and CDR.
Main Results:
- Estimated 997,500 incident pediatric TB cases in 2019, with 481,000 in children aged 0-4 and 516,500 in those aged 5-14.
- Paediatric case detection ratio (CDR) was lower for younger children (41% for 0-4 years) compared to older children (63% for 5-14 years).
- Global pediatric CDR improved significantly from 18% in 2013 to 53% in 2019, with notable progress in specific regions.
Conclusions:
- Substantial underreporting of pediatric TB cases likely leads to significant associated mortality.
- Strengthened TB diagnostic and reporting systems are essential for improving care and outcomes for children.
- Investment in research for better pediatric TB diagnostics is urgently needed in high-burden settings.
Background:
Many children who develop tuberculosis are thought to be missed by diagnostic and reporting systems. We aimed to estimate paediatric tuberculosis incidence and underreporting between 2013 and 2019 in countries representing more than 99% of the global tuberculosis burden.
Methods:
We developed a mathematical model of paediatric tuberculosis natural history, accounting for key mechanisms and risk factors for infectious exposure (HIV, malnutrition, and BCG non-vaccination), the probability of infection given exposure, and progression to disease among infected individuals. We extracted paediatric population estimates from UN Population Division data, and we used WHO estimates for adult tuberculosis incidence rates. We parameterised this model for 185 countries and calibrated it using data from countries with stronger case detection and reporting systems. Using this model, we estimated trends in paediatric incidence, and the proportion of these cases that are diagnosed and reported (case detection ratio [CDR]) for each country, age group, and year.
Findings:
For 2019, we estimated 997 500 (95% credible interval [CrI] 868 700-1 163 100) incident tuberculosis cases among children, with 481 000 cases (398 400-587 400) among those aged 0-4 years and 516 500 cases (442 900-608 000) among those aged 5-14 years. The paediatric CDR was estimated to be lower in children aged 0-4 years (41%, 95% CrI 34-50) than in those aged 5-14 years (63%, 53-75) and varied widely between countries. Estimated CDRs increased substantially over the study period, from 18% (15-20) in 2013 to 53% (45-60) in 2019, with improvements concentrated in the Eastern Mediterranean, South-East Asia, and Western Pacific regions. Over the study period, global incidence was estimated to have declined slowly at an average annual rate of 1·52% (1·42-1·66).
Interpretation:
Paediatric tuberculosis causes substantial morbidity and mortality, and these data indicate that cases (and, thus, probably associated mortality) are currently substantially underreported. These findings reinforce the need to ensure prompt diagnosis and care for children developing tuberculosis, strengthen reporting systems, and invest in research to develop more accurate and easy-to-use diagnostics for paediatric tuberculosis in high-burden settings.
Funding:
National Institutes of Health.
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