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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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Relationship between bone GLA-protein (BGP) and calcidiol (25-hydroxycalciferol) in serum of breast-fed infants

M Gruson, L Cancela, M A Denne

    Endocrinologia Experimentalis
    |August 1, 1986
    PubMed

    Insights

    Vitamin D supplementation in exclusively breast-fed infants increased serum osteocalcin levels, indicating enhanced bone metabolism. This study highlights the importance of vitamin D for infant bone health during early life.

    Area of Science:

    • Pediatrics
    • Endocrinology
    • Bone Metabolism

    Background:

    • Infant bone metabolism is crucial for healthy development.
    • Vitamin D status is vital for calcium and phosphorus homeostasis.
    • Osteocalcin serves as a marker for bone formation.

    Purpose of the Study:

    • To investigate the relationship between serum osteocalcin and vitamin D status in exclusively breast-fed infants.
    • To assess the impact of vitamin D supplementation on bone metabolism markers in early infancy.

    Main Methods:

    • Measured serum levels of calcium, phosphorus, alkaline phosphatase, 25-hydroxycalciferol (calcidiol), 1,25-dihydroxycalciferol (calcitriol), and osteocalcin (BGP).
    • Analyzed data from 22 lactating women and their paired infants before and after vitamin D supplementation (400 IU/day).

    Main Results:

    • Serum calcidiol and osteocalcin levels increased significantly after vitamin D supplementation.
    • Calcitriol levels did not show a significant change post-supplementation.
    • The observed increase in osteocalcin suggests enhanced bone activity.

    Conclusions:

    • Vitamin D supplementation positively influences bone metabolism in exclusively breast-fed infants.
    • Increased osteocalcin levels reflect the beneficial effect of vitamin D on infant bone health.
    • This study supports routine vitamin D supplementation for breast-fed infants.

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