Detection of retinopathy disease using morphological gradient and segmentation approaches in fundus images

Diabetes-related cases can cause glaucoma, cataracts, optic neuritis, paralysis of the eye muscles, or various retinal damages over time. Diabetic retinopathy is the most common form of blindness that occurs with diabetes. Diabetic retinopathy is a disease that occurs when the blood vessels in the retina of the eye become damaged, leading to loss of vision in advanced stages. This disease can occur in any diabetic patient, and the most important factor in treating the disease is early diagnosis. Nowadays, deep learning models and machine learning methods, which are open to technological developments, are already used in early diagnosis systems. In this study, two publicly available datasets were used. The datasets consist of five types according to the severity of diabetic retinopathy. The objectives of the proposed approach in diabetic retinopathy detection are to positively contribute to the performance of CNN models by processing fundus images through preprocessing steps (morphological gradient and segmentation approaches). The other goal is to detect efficient sets from type-based activation sets obtained from CNN models using Atom Search Optimization method and increase the classification success.

The proposed approach consists of three steps. In the first step, the Morphological Gradient method is used to prevent parasitism in each image, and the ocular vessels in fundus images are extracted using the segmentation method. In the second step, the datasets are trained with transfer learning models and the activations for each class type in the last fully connected layers of these models are extracted. In the last step, the Atom Search optimization method is used, and the most dominant activation class is selected from the extracted activations on a class basis.

When classified by the severity of diabetic retinopathy, an overall accuracy of 99.59% was achieved for dataset #1 and 99.81% for dataset #2.

In this study, it was found that the overall accuracy achieved with the proposed approach increased. To achieve this increase, the application of preprocessing steps and the selection of the dominant activation sets from the deep learning models were implemented using the Atom Search optimization method.