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Related Experiment Video

Updated: Oct 10, 2025

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Core-shell microparticles: From rational engineering to diverse applications.

Xiaoli Zhang1, Qingli Qu1, Aying Zhou1

  • 1Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, PR China.

Advances in Colloid and Interface Science
|December 13, 2021
PubMed
Summary
This summary is machine-generated.

Biodegradable core-shell microparticles offer versatile biomedical applications. This review highlights advanced designs, fabrication methods like microfluidics, and their potential in artificial cells and drug delivery systems.

Keywords:
Artificial cellCore-shell microparticlesDrug releaseGas-shearing strategyMicrofluidics technology

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Core-shell microparticles are advanced carriers with solid, liquid, or gas cores and protective shells.
  • These microparticles show significant promise for diverse biomedical applications.
  • Recent advancements focus on biodegradable systems for enhanced biocompatibility and controlled release.

Purpose of the Study:

  • To provide a comprehensive overview of recent developments in biodegradable core-shell microparticle design and applications.
  • To discuss emerging fabrication methodologies and their advantages.
  • To highlight the potential of these systems in artificial cells, drug delivery, and cell culture.

Main Methods:

  • Review of recent literature on core-shell microparticle fabrication and applications.
  • Detailed discussion of microfluidics technology for precise microparticle generation.
  • Exploration of self-assembly, gas-shearing, and coaxial electrospray techniques.

Main Results:

  • Biodegradable core-shell microparticles are versatile carriers with tunable properties.
  • Microfluidics offers superior control for generating complex multi-core structures.
  • These systems demonstrate significant potential in creating artificial cells, controlled drug release, and improved cell culture environments.

Conclusions:

  • Core-shell microparticles, particularly biodegradable ones, are highly promising for biomedical innovations.
  • Advanced fabrication techniques like microfluidics are key to unlocking their full potential.
  • Further research is needed to address current limitations and propel the field forward.