Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding the role of burnout on nurses' quit intentions in the context of healthcare organizations of Hungary.

Scientific reports·2026
Same author

Reliable Change Indices and Standardized Regression Norms for the Hungarian version of the BICAMS questionnaire.

Multiple sclerosis and related disorders·2026
Same author

The Effect of Artificial Insemination and Multiple Ovulation Embryo Transfer on Production, Health Status, and Survival of Holstein-Friesian Cows.

Veterinary sciences·2026
Same author

Disrupting pegRNA intramolecular complementarity via PBS and spacer sequence alterations can enhance prime editing efficiency.

Nucleic acids research·2026
Same author

Functional connectivity-based attractor dynamics of the human brain in rest, task, and disease.

eLife·2026
Same author

DenseLes: slice-wise dense network for multiple sclerosis lesion segmentation and classification.

Frontiers in neurology·2026

Related Experiment Video

Updated: Oct 10, 2025

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.5K

Connection between microstructural alterations detected by diffusion MRI and cognitive dysfunction in MS: A

Péter Faragó1, Eszter Tóth2, Nikoletta Szabó N1

  • 1Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.

Multiple Sclerosis and Related Disorders
|December 13, 2021
PubMed
Summary

Cognitive decline in Multiple Sclerosis (MS) is linked to white matter changes. This study used partial least squares to connect diffusion parameters to cognitive performance, revealing distinct patterns for visual memory and language functions.

Keywords:
BICAMSDTIPLSTBSS

More Related Videos

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.6K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.7K

Related Experiment Videos

Last Updated: Oct 10, 2025

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.5K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.6K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.7K

Area of Science:

  • Neuroimaging
  • Neuroscience
  • Medical Imaging

Background:

  • Cognitive decline is a significant symptom in Multiple Sclerosis (MS).
  • The precise relationship between cognitive status and white matter microstructural changes in MS remains unclear.
  • Understanding these links is crucial for managing MS-related cognitive impairment.

Purpose of the Study:

  • To characterize the relationship between white matter microstructure and cognitive performance in MS patients.
  • To identify specific diffusion parameter patterns associated with cognitive dysfunction using a partial least squares (PLS) approach.

Main Methods:

  • Analysis of T1 and Diffusion Tensor Imaging (DTI) data from 53 Relapsing-Remitting MS (RRMS) patients.
  • Utilized the Brief Visuospatial Memory Test (BVMT) and Single Digit Modality Test (SDMT) for cognitive assessment.
  • Applied a PLS approach to correlate diffusion parameters with cognitive test results.

Main Results:

  • The study identified distinct patterns of white matter alterations related to different cognitive functions.
  • Demyelination was associated with the first latent variable, while axonal damage was linked to the second and third.
  • Specific brain regions like the corpus callosum, thalamus, and superior longitudinal fascicle showed diffusion alterations correlating with cognitive performance.

Conclusions:

  • Visual memory and language functions rely on distinct white matter diffusion parameter patterns and spatial organization.
  • Axial diffusivity alterations, indicative of axonal loss, explained approximately 20% of the variability in cognitive functions.
  • These findings highlight the complex relationship between white matter integrity and cognitive impairment in MS.