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Updated: Oct 10, 2025

Metabolic Labeling of Leucine Rich Repeat Kinases 1 and 2 with Radioactive Phosphate
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LRRK2 signaling in neurodegeneration: two decades of progress

Lucia Iannotta1, Elisa Greggio1

  • 1Department of Biology, University of Padova, Padova, Italy.

Essays in Biochemistry
|December 13, 2021
PubMed

Insights

Leucine-rich repeat kinase 2 (LRRK2) is a key protein in cellular pathways. Understanding LRRK2

Area of Science:

  • Neuroscience
  • Cell Biology
  • Genetics

Background:

  • Leucine-rich repeat kinase 2 (LRRK2) is a complex GTPase/kinase.
  • LRRK2 regulates cytoskeletal dynamics and the endolysosomal pathway.
  • LRRK2 mutations are linked to Parkinson's disease (PD) and other neurodegenerative and inflammatory conditions.

Purpose of the Study:

  • To review major discoveries in LRRK2 pathobiology.
  • To highlight progress in LRRK2 inhibition for neurodegenerative diseases.

Main Methods:

  • Literature review of LRRK2 research.
  • Analysis of LRRK2's role in cellular pathways and disease.

Main Results:

  • LRRK2 interacts with numerous partners and phosphorylates Rab GTPases.
  • Genetic variations in LRRK2 are associated with sporadic PD and progressive supranuclear palsy.
  • LRRK2 pathobiology research has advanced significantly.

Conclusions:

  • LRRK2 is a critical protein in neurodegeneration.
  • LRRK2 inhibition shows promise as a therapeutic strategy for PD and related disorders.
Keywords:
LRRK2cytoskeletongliainflammationkinase inhibitionvesicular pathways

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