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Echocardiographic features of acute-phase microscopic polyangiitis in Japanese patients: A single-centre

Takashi Nawata1, Natsu Kinoshita1, Shinichi Okuda1

  • 1Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Modern Rheumatology
|December 13, 2021
PubMed
Abstract

Insights

Microscopic polyangiitis (MPA) patients show left atrial enlargement and diastolic dysfunction during acute phases. Cardiac assessment is crucial, particularly with high inflammation levels.

Area of Science:

  • Cardiology
  • Rheumatology
  • Diagnostic Imaging

Background:

  • Microscopic polyangiitis (MPA) is a systemic vasculitis affecting multiple organs.
  • Echocardiographic manifestations in acute-phase MPA remain incompletely understood.

Purpose of the Study:

  • To investigate the echocardiographic features of Japanese patients in the acute phase of MPA.
  • To compare cardiac parameters between MPA patients and healthy controls.

Main Methods:

  • Retrospective analysis of 15 MPA patients undergoing echocardiography within two weeks of steroid therapy initiation.
  • Comparison of echocardiographic parameters with 30 age- and sex-matched controls.

Main Results:

  • MPA patients exhibited significantly larger left atrial (LA) diameter and LA volume index.
  • Elevated early diastolic filling velocity, diastolic pulmonary venous flow velocity, and trans-tricuspid pressure gradient were observed in MPA patients.
  • Increased left ventricular (LV) stiffness, indicated by shorter deceleration time (DCT), correlated with C-reactive protein levels.

Conclusions:

  • Acute-phase MPA is associated with left atrial dilatation and left ventricular diastolic dysfunction.
  • Findings suggest increased LV stiffness contributes to diastolic dysfunction and subsequent LA enlargement.
  • Cardiac evaluation is essential for MPA patients, especially those with pronounced inflammatory responses.
Keywords:
Echocardiographyleft ventricle diastolic dysfunctionmicroscopic polyangiitis

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