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Melanoma trials that defined surgical management: Brief overview of current/upcoming adjuvant/neoadjuvant trials

Ankit Patel1, Joseph Skitzki1,2

  • 1Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

Journal of Surgical Oncology
|December 13, 2021
PubMed

Insights

Systemic therapies, including immunotherapy and targeted treatments, are revolutionizing adjuvant and neoadjuvant care for high-risk cutaneous melanoma. These advancements offer potential for better outcomes in patients with resected Stage III and IV disease.

Area of Science:

  • Oncology
  • Dermatology
  • Clinical Trials

Background:

  • Cutaneous melanoma treatment has evolved significantly.
  • Adjuvant systemic therapy is a critical area of research.

Purpose of the Study:

  • To review the shifts in adjuvant systemic therapy for cutaneous melanoma.
  • To explore the application of immunotherapies and targeted therapies in the adjuvant and neoadjuvant settings.

Main Methods:

  • Review of recent clinical trial data.
  • Analysis of therapeutic successes in metastatic melanoma.
  • Investigation of neoadjuvant and adjuvant treatment strategies.

Main Results:

  • Immunotherapies and targeted therapies show promise.
  • Successful translation from metastatic to earlier settings (adjuvant/neoadjuvant).

Conclusions:

  • High-risk resected Stage III and IV melanoma patients may benefit from novel systemic therapies.
  • Ongoing research aims to improve clinical outcomes through early intervention.
Keywords:
BRAFPD-1clinical trialsimmunotherapy

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