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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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The gut microbiota profile in psoriasis: a Brazilian case-control study
L Schade1, D Mesa2, A R Faria3
1Department of Internal Medicine, Federal University of Paraná, Curitiba, Brazil.
Letters in Applied Microbiology
|December 13, 2021
Summary
Psoriasis patients show altered gut microbiota composition and reduced diversity compared to healthy individuals. Specific bacterial genera and species, including Prevotella copri, were increased, while others like Akkermansia muciniphila were decreased.
Area of Science:
- Immunodermatology
- Microbiome Research
- Gastroenterology
Background:
- Psoriasis is a chronic inflammatory skin disease with unclear pathogenesis.
- An association between psoriasis and intestinal inflammation suggests a role for the gut microbiota.
- Recent research focuses on the gut microbiota's influence on psoriasis immune responses.
Purpose of the Study:
- To evaluate the gut microbiota composition and diversity in individuals with psoriasis.
- To compare the gut microbiota of psoriasis patients with that of healthy controls.
Main Methods:
- Collected stool samples from 21 psoriasis patients and 24 healthy controls.
- Analyzed samples using 16S rRNA gene sequencing.
- Matched participants by sex, age, BMI, comorbidities, and smoking status.
Main Results:
- Psoriasis patients had increased levels of the Dialister genus and Prevotella copri species.
- Reduced levels of Ruminococcus, Lachnospira, Blautia genera, and Akkermansia muciniphila species were observed in psoriasis patients.
- Psoriasis patients exhibited significantly lower gut microbiota diversity compared to controls.
Conclusions:
- Gut microbiota alterations are associated with psoriasis.
- Reduced microbial diversity and specific compositional changes may contribute to psoriasis pathogenesis.
- Further research is warranted to explore therapeutic interventions targeting the gut microbiota in psoriasis.
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