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Related Concept Videos

Blood Types02:20

Blood Types

19.1K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
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The ABO Blood Group01:12

The ABO Blood Group

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The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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Rh Blood Group01:19

Rh Blood Group

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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Related Experiment Video

Updated: Oct 10, 2025

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

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BGvar: A comprehensive resource for blood group immunogenetics.

Mercy Rophina1,2, Kavita Pandhare1,2, Sudhir Jadhao3,4

  • 1Genome Informatics and Big Data, CSIR Institute of Genomics and Integrative Biology, Delhi, India.

Transfusion Medicine (Oxford, England)
|December 13, 2021
PubMed
Summary

A new online resource, BGvar, now provides a comprehensive catalog of human blood group alleles and their genomic variations. This resource facilitates the application of genomic technologies for blood group characterization and interpretation.

Keywords:
blood group allelescurationdatabasefunctional annotationonline resource

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Area of Science:

  • Genetics and Genomics
  • Immunogenetics
  • Bioinformatics

Background:

  • Blood groups are critical for safe transfusions and are genetically determined.
  • Existing genomic resources lacked comprehensive data on red cell antigens.
  • This gap limited the use of genomic technologies for blood group analysis.

Purpose of the Study:

  • To create a manually curated, genome-ready dataset of human blood group alleles.
  • To facilitate the interpretation of genomic data for blood group determination.

Main Methods:

  • Systematic annotation of public datasets for allele frequencies and functionality.
  • Literature review to collate phenotype and clinical importance data.
  • Manual curation of genomic variants related to blood groups.

Main Results:

  • The Blood Group Associated Genomic Variant Resource (BGvar) was compiled.
  • BGvar includes 1700 ISBT-approved and 1706 literature-curated alleles across 43 blood group systems.
  • The resource contains various genetic variations including SNVs, InDels, CNVs, and gene rearrangements.

Conclusions:

  • BGvar is a comprehensive, user-friendly online resource for human blood group alleles.
  • It addresses the need for a manually compiled, genome-ready dataset.
  • BGvar is accessible online at http://clingen.igib.res.in/bgvar/.