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Related Experiment Video

Updated: Oct 10, 2025

Method of Studying Palatal Fusion using Static Organ Culture
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Speech Development in Cleft Palate with and without Robin Sequence.

Andreas Naros1, Sylva Bartel1, Margit Bacher1

  • 1From the Department of Oral and Maxillofacial Surgery, Interdisciplinary Center for Cleft Palate and Craniofacial Malformations, Department of Orthodontics, and Department of Neonatology, Tuebingen University Hospital; Section of Phoniatrics and Paedaudiology, Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Halle; BIP-Orthodontic Practice; and Department of Clinical Epidemiology and Applied Biometry, University of Tuebingen.

Plastic and Reconstructive Surgery
|December 13, 2021
PubMed
Summary
This summary is machine-generated.

Children with isolated Robin sequence and cleft palate show comparable speech development to those with cleft palate alone by age 5-6. This suggests isolated Robin sequence does not inherently risk impaired speech outcomes.

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Area of Science:

  • Craniofacial Surgery
  • Pediatric Speech Pathology
  • Genetics and Developmental Biology

Background:

  • Robin sequence is characterized by micrognathia, glossoptosis, and airway obstruction, frequently associated with cleft palate (up to 85%).
  • Previous research indicates potential speech development delays in children with Robin sequence following cleft palate repair.
  • This study focuses on comparing speech outcomes in children with isolated Robin sequence and cleft palate versus those with cleft palate only.

Purpose of the Study:

  • To investigate and compare speech development at 5 to 6 years of age.
  • To determine if isolated Robin sequence poses a risk for impaired speech development after cleft palate repair.
  • To analyze speech parameters using standardized assessment tools.

Main Methods:

  • A cohort of 44 children (22 with Robin sequence, 22 with cleft palate only) was studied.
  • Robin sequence patients received Tübingen palatal plate treatment postnatally.
  • Speech assessments utilized the German version of the Great Ormond Street Speech Assessment and Universal Reporting Parameters for Cleft Palate Speech, analyzed by blinded phoniatricians.

Main Results:

  • No significant group differences in speech development were observed at 5 to 6 years of age.
  • While Robin sequence children had more severe clefts and were older at surgery, their speech outcomes were comparable.
  • The median total speech score was similar between groups, indicating no statistically significant effect of Robin sequence on speech development.

Conclusions:

  • Isolated Robin sequence, in conjunction with cleft palate, does not appear to negatively impact speech development at school age.
  • Early intervention with palatal plates may contribute to favorable speech outcomes in Robin sequence patients.
  • Further research can explore long-term speech trajectories and the impact of specific surgical techniques.