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Tumor Doubling Time Using CT Volumetric Segmentation in Metastatic Adrenocortical Carcinoma
Sarah N Fuller1, Ahmad Shafiei2, David J Venzon3
1Pediatric Oncology Branch, Rare Tumor Initiative, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Current Oncology (Toronto, Ont.)
|December 13, 2021
Summary
Adrenocortical carcinoma (ACC) liver metastases grow significantly faster than lung or lymph node lesions. This finding highlights the need for prompt intervention in liver-dominant ACC cases.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Adrenocortical carcinoma (ACC) is a rare cancer with a poor prognosis.
- Metastatic ACC lesions in the liver often exhibit accelerated growth, necessitating urgent treatment.
Purpose of the Study:
- To quantitatively compare the growth rates of metastatic adrenocortical carcinoma lesions in the liver, lungs, and lymph nodes.
- To determine the volume doubling time for ACC metastases across different organ systems.
Main Methods:
- Retrospective review of computed tomography (CT) scans from 12 patients with metastatic ACC.
- Volumetric segmentation analysis of up to five metastatic lesions per organ (liver, lung, lymph nodes).
- Statistical comparison of lesion volumetric growth rates and calculation of volume doubling times.
Main Results:
- A total of 92 lesions were evaluated across 12 patients.
- The volume doubling time for liver lesions was significantly shorter (27 days) compared to lung (90 days) and lymph node lesions (95 days).
- Liver metastases demonstrated a markedly faster growth rate.
Conclusions:
- Metastatic adrenocortical carcinoma lesions in the liver exhibit a substantially faster growth rate than those in the lungs or lymph nodes.
- These findings underscore the clinical observation of rapid liver lesion progression in ACC.
- The results emphasize the importance of vigilant monitoring and timely therapeutic strategies for liver metastases in ACC patients.
