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Related Concept Videos

CRISPR and crRNAs02:53

CRISPR and crRNAs

17.8K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
17.8K
The Antiviral System of Bacteria and Archaea: CRISPR01:23

The Antiviral System of Bacteria and Archaea: CRISPR

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CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats is a adaptive immune system found in bacteria and archaea that protects against viral infections. This system enables prokaryotic cells to identify, remember, and neutralize foreign genetic elements, primarily bacteriophages, by storing fragments of the invader’s DNA as a genetic memory.The CRISPR immune response begins during an initial infection. Cas (CRISPR-associated) proteins play a central role in this...
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CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

588
The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
588
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

310
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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CRISPR01:59

CRISPR

53.4K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Antibiotic Selection00:57

Antibiotic Selection

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Overview
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Related Experiment Video

Updated: Oct 10, 2025

Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira
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Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira

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Correction: CRISPR-based antimicrobials to obstruct antibiotic-resistant and pathogenic bacteria.

Dennise Palacios Araya, Kelli L Palmer, Breck A Duerkop

    Plos Pathogens
    |December 13, 2021
    PubMed
    Summary

    This study corrects a previous article DOI. The correct DOI is 10.1371/journal.ppat.1009672.

    Area of Science:

    • This study falls under the domain of infectious diseases and molecular biology.

    Context:

    • The article provides a correction to a previously published study.
    • The correction pertains to the Digital Object Identifier (DOI) of the article.

    Purpose:

    • To ensure accurate citation and retrieval of the scientific work.
    • To rectify the bibliographic information for the specific publication.

    Summary:

    • The abstract serves as a correction notice for an article.
    • It clarifies the correct DOI for the publication, which is 10.1371/journal.ppat.1009672.

    Impact:

    • Ensures researchers can correctly access and cite the intended study.
    • Maintains the integrity of scientific literature and record-keeping.

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