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Higher Peripheral Cholesterol and a Positive Correlation With Risk for Large-For-Gestational-Age Neonates in

Dongyu Wang1, Wenjing Ding1, Chengcheng Ding1

  • 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Frontiers in Endocrinology
|December 13, 2021
PubMed

Insights

High cholesterol in underweight pregnant women increases risks for large-for-gestational-age (LGA) infants, particularly with excessive weight gain. Lipid and weight management are crucial for these women.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Nutritional Science

Background:

  • Underweight pregnant women face risks due to inadequate weight gain and lipid management.
  • Adverse pregnancy outcomes are linked to nutritional status and metabolic profiles during gestation.

Purpose of the Study:

  • To investigate the association between lipid profiles and adverse pregnancy outcomes in pre-pregnancy underweight women.
  • To determine if lipid levels predict risks like large-for-gestational-age (LGA) or small-for-gestational-age (SGA) in underweight pregnancies.

Main Methods:

  • A cohort study of 6,223 Chinese gravidas (January 2015 - December 2016).
  • Women were classified as underweight, normal-weight, or overweight based on pre-pregnancy BMI.
  • Logistic regression analyzed second-trimester lipid profiles against obstetric outcomes, with subgroup analysis for gestational weight gain relative to Institute of Medicine (IOM) recommendations.

Main Results:

  • Underweight women had higher total cholesterol (TC) than overweight women (P <0.001).
  • Elevated TC correlated positively with LGA risk [aOR=2.24] and negatively with SGA risk [aOR=0.71] in underweight women.
  • This TC-LGA association was significant only in underweight women with gestational weight gain exceeding IOM recommendations.

Conclusions:

  • Underweight pregnant women with high TC levels face increased LGA risk, especially with excessive gestational weight gain.
  • Clinical management of both lipids and weight gain is recommended for underweight pregnant women to mitigate adverse outcomes.
Abstract

Keywords:
LGA large for gestational ageSGA (small for gestational age)cholesteroloverweightunderweight

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