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Positive Association between Triglyceride-Rich Lipoprotein Cholesterol and Diabetes Mellitus in Hypertensive Patients

Wei Zhou1, Yu Yu2,3, Lingjuan Zhu1

  • 1Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

International Journal of Endocrinology
|December 13, 2021
PubMed

Insights

Triglyceride-rich lipoprotein cholesterol (TRL-C) is positively associated with diabetes mellitus (DM) in hypertensive patients. A healthy lifestyle does not alter this significant relationship, suggesting TRL-C as a potential marker for DM.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • The link between triglyceride-rich lipoprotein cholesterol (TRL-C) and diabetes mellitus (DM) is not well-established.
  • Limited research exists on TRL-C's independent association with DM, particularly in hypertensive individuals.

Purpose of the Study:

  • To investigate the independent association between TRL-C and DM in hypertensive patients.
  • To determine if a healthy lifestyle influences the TRL-C and DM relationship.

Main Methods:

  • Analysis of data from 13,721 hypertensive patients not on lipid-lowering drugs.
  • TRL-C calculated as TC - (LDL-C + HDL-C).
  • DM defined by fasting plasma glucose ≥7.0 mmol/L and/or hypoglycemic drug use.

Main Results:

  • A significant positive association was found between TRL-C and DM (OR: 1.73, 95% CI: 1.54-1.94) after adjusting for confounders.
  • A healthy lifestyle did not modify this association (interaction P=0.38).
  • Subgroup analysis showed similar ORs for healthy lifestyle (1.93) and non-healthy lifestyle (1.72) groups.

Conclusions:

  • TRL-C is positively associated with DM in hypertensive patients.
  • A healthy lifestyle does not attenuate the TRL-C and DM link.
  • TRL-C may serve as a valuable marker for DM prevention and treatment strategies.
Abstract

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