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Related Experiment Video

Updated: Oct 10, 2025

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
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Surfactant Stock Optimization for Cost Minimization in Neonatal Intensive Care Units.

Müfide Narli1, Ali Kokangül1

  • 1Industrial Engineering, Cukurova University, Adana, Turkey.

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|December 13, 2021
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Summary

This study presents a mathematical model to optimize surfactant inventory management for newborns, minimizing costs and waste while ensuring availability for respiratory insufficiency treatment.

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Area of Science:

  • Neonatal care
  • Healthcare logistics
  • Mathematical modeling

Background:

  • Surfactant deficiency causes neonatal respiratory insufficiency, a leading cause of infant mortality.
  • Accurate surfactant dosing is critical but challenging due to unpredictable patient arrivals and weight fluctuations.
  • Ensuring timely surfactant availability for emergency interventions is paramount.

Purpose of the Study:

  • To develop a mathematical model for optimizing surfactant inventory.
  • To minimize costs associated with purchasing, ordering, holding, and waste.
  • To determine optimal preparation/vial usage, reorder points, and order quantities.

Main Methods:

  • Developed a mathematical model incorporating continuous inventory control.
  • Accounted for stochastic variables like patient arrival times and weight changes.
  • Validated the model using real data from a 66-bed neonatal intensive care unit.

Main Results:

  • The model successfully minimizes combined inventory costs (purchase, order, holding, waste).
  • Identified optimal strategies for surfactant preparation and vial utilization.
  • Established effective reorder points and order quantities for continuous supply.

Conclusions:

  • The developed mathematical model provides an efficient approach to surfactant inventory management.
  • Optimized inventory control reduces healthcare costs and minimizes surfactant waste.
  • This model ensures critical surfactant availability for neonatal respiratory insufficiency treatment.