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Updated: Oct 10, 2025
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A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
Published on: April 11, 2014
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Pharmacological dose ascorbic acid administration in relapsed refractory multiple myeloma patients
Ali Zahit Bolaman1, Atakan Turgutkaya1, Hilal Eroğlu Küçükdiler1
1School of Medicine, Department of Medicine AYDIN/TURKIYE, Aydin Adnan Menderes University, Aydın, Turkey.
Leukemia Research Reports
|December 13, 2021
Summary
High-dose ascorbic acid (vitamin C) shows promise as an add-on therapy for relapsed refractory multiple myeloma. This approach may improve treatment outcomes in patients resistant to conventional chemotherapy.
Area of Science:
- Oncology
- Hematology
- Pharmacology
Background:
- High-dose ascorbic acid exhibits pro-oxidant effects, generating reactive oxygen species that induce cancer cell death.
- Ascorbic acid is explored as an adjunctive treatment in various malignancies due to its cytotoxic potential.
Observation:
- Pharmacological doses of intravenous ascorbic acid (15 g/week) were administered to relapsed refractory multiple myeloma patients.
- Patients received this combination alongside carfilzomib-lenalidomide-dexamethasone chemotherapy after failing to respond to initial treatment.
Findings:
- In a cohort of 4 heavily pretreated patients (6-9 prior lines of therapy), 1 achieved complete response.
- The remaining 3 patients experienced very good partial responses after 4 cycles of combination therapy.
Implications:
- Pharmacological doses of ascorbic acid may enhance conventional chemotherapy efficacy in relapsed refractory multiple myeloma.
- Further clinical trials with larger patient cohorts are warranted to validate these findings and establish optimal dosing for plasma cell disorders.
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