Related Experiment Video

Updated: Oct 10, 2025

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

886

Hypertension and COVID-19: Updates from the era of vaccines and variants

Sowmya Swamy1, Christian A Koch2, Fady Hannah-Shmouni3

  • 1Department of Internal Medicine, George Washington University Medical Center, Washington, DC, USA.

Journal of Clinical & Translational Endocrinology
|December 13, 2021
PubMed

Insights

This review examines how hypertension impacts COVID-19 severity and discusses the role of blood pressure medications. It also covers the latest on SARS-CoV-2 variants and vaccines for hypertensive patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a significant global health concern.
  • Hypertension and older age are linked to increased COVID-19 severity and mortality.
  • Antihypertensive agents' role in COVID-19 pathogenesis is under extensive investigation.

Purpose of the Study:

  • To review pathophysiologic interactions between hypertension and COVID-19.
  • To provide updated information on SARS-CoV-2 variants and vaccines in hypertensive individuals.

Main Methods:

  • Literature review of existing studies on hypertension, COVID-19, and antihypertensive agents.
  • Analysis of current research on SARS-CoV-2 variants and vaccine implications.

Main Results:

  • Hypertension is a significant risk factor for severe COVID-19 outcomes.
  • Antihypertensive medications' effects on COVID-19 are complex and require ongoing study.
  • Emerging SARS-CoV-2 variants and vaccines necessitate updated considerations for hypertensive patients.

Conclusions:

  • Understanding the interplay between hypertension and COVID-19 is crucial for patient management.
  • Further research is needed to clarify the role of antihypertensive agents in the context of new variants and vaccines.
  • Tailored strategies are essential for protecting hypertensive populations from severe COVID-19.

Keywords:
ACE inhibitorsAlpha blockersAngiotensin receptor blockersBeta blockersCOVID-19Calcium channel blockersCatecholaminesDelta variantHypertensionSARS-CoV-2Vaccines

More Related Videos

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells09:29

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Published on: March 5, 2019

5.8K
Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

7.7K

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.3K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
139
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
141
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
72
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
72
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
101