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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Association of antidiabetic therapy with shortened telomere length in middle-aged Type 2 diabetic patients

Tahreer Mohammed Al-Thuwaini1

  • 1Department of Animal Production, College of Agriculture, Al-Qasim Green University, Al-Qasim, Babil 51001 Iraq.

Journal of Diabetes and Metabolic Disorders
|December 13, 2021
PubMed
Abstract

Insights

Doanil therapy shows better management of diabetes and less telomere shortening compared to insulin therapy in middle-aged patients. This study investigates antidiabetic drugs and their effect on telomere length.

Area of Science:

  • Endocrinology and Metabolism
  • Genetics and Molecular Biology

Background:

  • Antidiabetic therapies aim to manage diabetes but can have adverse effects.
  • Telomere length is a biomarker for cellular aging and may be influenced by disease and treatment.

Purpose of the Study:

  • To investigate the association between antidiabetic therapy and telomere length in middle-aged Type 2 diabetic patients.
  • To compare the effects of Doanil, insulin, and combination therapy on telomere length.

Main Methods:

  • Case-control study involving 300 Type 2 diabetic patients and 100 non-diabetic controls (ages 30-50).
  • Telomere length measured using southern blotting.
  • Logistic regression analysis to determine the relationship between therapy and telomere length.

Main Results:

  • Diabetic patients on treatment had better glucose and lipid profiles than untreated patients.
  • Patients on Doanil or combination therapy had longer telomeres than those on insulin therapy.
  • Insulin therapy was significantly associated with diabetic risk factors and shorter telomere length.

Conclusions:

  • Doanil therapy demonstrated greater efficacy in managing diabetic risk factors and preserving telomere length compared to insulin therapy.
  • Findings suggest differential impacts of antidiabetic medications on cellular aging markers.
Keywords:
Antidiabetic therapyTelomere lengthType 2 diabetes

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