Related Experiment Video
Updated: Oct 10, 2025

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
Published on: July 21, 2023
Personalized medicine in cardiovascular disease: review of literature
Ali Sheikhy1, Aida Fallahzadeh1, Hamid Reza Aghaei Meybodi2
1Research Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Purpose:
Personalized medicine (PM) is the concept of managing patients based on their characteristics, including genotypes. In the field of cardiology, advantages of PM could be found in the diagnosis and treatment of several conditions such as arrhythmias and cardiomyopathies; moreover, it may be beneficial to prevent adverse drug reactions (ADR) and select the best medication. Genetic background can help us in selecting effective treatments, appropriate dose requirements, and preventive strategies in individuals with particular genotypes.
Method:
In this review, we provide examples of personalized medicine based on human genetics for the most used pharmaceutics in cardiology, including warfarin, clopidogrel, and statins. We also review cardiovascular diseases, including coronary artery disease, arrhythmia, and cardiomyopathies.
Conclusion:
Genetic factors are as important as environmental factors and they should be tested and evaluated more in the future by improving in genetic testing tools.
Supplementary Information:
The online version contains supplementary material available at 10.1007/s40200-021-00840-0.
Related Concept Videos
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cardiovascular Drugs: Classification based on Therapeutic Indications
Atherosclerosis III: Management
Coronary Artery Disease I: Introduction
Coronary Artery Disease IV: Preventive Measures
Cardiomyopathy V: Interprofessional Care

