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Related Concept Videos

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Updated: Oct 10, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Recent Metabolomics Analysis in Tumor Metabolism Reprogramming.

Jingjing Han1, Qian Li1, Yu Chen1

  • 1Department of Anesthesiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Frontiers in Molecular Biosciences
|December 13, 2021
PubMed
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Metabolomics reveals how cancer cells reprogram metabolism, aiding in early biomarker discovery and personalized treatment strategies. This technique tracks metabolic changes to improve cancer development and therapy insights.

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Area of Science:

  • Oncology
  • Metabolomics
  • Biochemistry

Background:

  • Metabolic reprogramming is a key characteristic of cancer progression.
  • Metabolomic analysis offers a feasible method to track dynamic changes in tumor metabolism and treatment response.
  • Numerous studies highlight metabolomics' application in tumor metabolic reprogramming research.

Purpose of the Study:

  • To review how metabolomics elucidates the impact of tumor microenvironment metabolic changes on major tumor metabolic pathways.
  • To discuss metabolomics' role in identifying early cancer biomarkers from biofluids.
  • To explore metabolomics' utility in predicting drug responses, assessing efficacy, and monitoring resistance.

Main Methods:

  • Metabolomic analysis of tumor metabolic profiles.
  • Analysis of non-invasive biofluids for clinical information.
  • Application of stable isotope tracer technology to track metabolite activity.

Main Results:

  • Metabolomics aids in understanding the effects of metabolic reprogramming on tumor pathways.
  • Non-invasive biofluids can yield early biomarkers for tumor development.
  • Metabolomics can predict individual drug responses and monitor resistance.

Conclusions:

  • Metabolomics is crucial for understanding cancer development and treatment.
  • Stable isotope tracing enhances the study of deep metabolic pathways.
  • The multifaceted applications of metabolomics are vital in oncology research.