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Related Experiment Video

Updated: Oct 10, 2025

Author Spotlight: Utilizing Infraorbital Nerve Ligation in Mice for Investigating Trigeminal Neuropathic Pain and Treatment Strategies

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Trichodynia Revisited.

Ralph M Trüeb¹, Michela V R Starace², Bianca Maria Piraccini²

¹Center for Dermatology and Hair Diseases Professor Trüeb, Wallisellen, Switzerland.

Skin Appendage Disorders

|December 13, 2021

Summary

This summary is machine-generated.

Trichodynia, or scalp pain associated with hair loss, is common in various conditions, not just telogen effluvium. Research shows it lacks correlation with hair loss activity or inflammation, suggesting complex neural and psychosomatic factors.

Keywords:

Botulinum toxin Neuropeptide substance P Scalp dysesthesia Symptomatic scalp Trichodynia

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Published on: April 29, 2013

Area of Science:

Dermatology
Neuroscience
Psychosomatics

Background:

Trichodynia is scalp pain linked to hair loss complaints.
Initially associated with telogen effluvium, it's now recognized in androgenetic alopecia and with psychopathologic findings.
Studies have not found correlations between trichodynia and quantifiable hair loss or follicular inflammation.

Purpose of the Study:

To explore the diverse etiologies of scalp pain (trichodynia).
To investigate the role of neuropeptides in scalp sensation and nociception.
To advocate for a more descriptive approach to scalp conditions based on sensation and disease association.

Main Methods:

Review of existing studies on trichodynia and scalp conditions.
Consideration of neuro-immuno-cutaneous interactions.
Analysis of potential psychosomatic influences on scalp symptoms.

Main Results:

Trichodynia is not exclusively linked to telogen effluvium or follicular inflammation.
Neuropeptides may mediate scalp sensations by connecting the central nervous system to skin systems.
Emotional distress and external stimuli can trigger scalp nociception.

Conclusions:

A single term, trichodynia, may not adequately encompass the varied causes of scalp pain.
Describing scalp sensations based on specific disease associations is recommended.
Further research is needed on neural, endothelial, and follicular interactions in hair disorders and psychosomatic scalp conditions.