Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

9
Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
9
Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

3.1K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
3.1K
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

8
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
8
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

3.4K
Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
3.4K
Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

1.1K
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
1.1K
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

8
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
8

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The plasticity of biocompatibility.

Biomaterials·2023
Same author

Longer-Term Anti-VEGF Therapy Outcomes in Neovascular Age-Related Macular Degeneration, Diabetic Macular Edema, and Vein Occlusion-Related Macular Edema: Clinical Outcomes in 130 247 Eyes.

Ophthalmology. Retina·2022
Same author

The Technological Basis of a Balloon-Expandable TAVR System: Non-occlusive Deployment, Anchorage in the Absence of Calcification and Polymer Leaflets.

Frontiers in cardiovascular medicine·2022
Same author

Long-Term Stability and Biocompatibility of Pericardial Bioprosthetic Heart Valves.

Frontiers in cardiovascular medicine·2021
Same author

TAVR for Patients With Rheumatic Heart Disease: Opening the Door for the Many?

Journal of the American College of Cardiology·2021
Same author

Biocompatibility Pathways: Biomaterials-Induced Sterile Inflammation, Mechanotransduction, and Principles of Biocompatibility Control.

ACS biomaterials science & engineering·2021
Same journal

A senescent metabolism-modulating hierarchical scaffold restores NAD<sup>+</sup> homeostasis and redox balance for aged bone repair.

Bioactive materials·2026
Same journal

Intelligent responsive alloy scaffold temporally regulates the immune-osteogenic axis for the treatment of infectious bone defects.

Bioactive materials·2026
Same journal

Polymer-Zn(II) sunscreens for protection against harmful blue ray.

Bioactive materials·2026
Same journal

M1 macrophage-derived exosomal miR-155-5p exacerbates aortic dissection via SMAD5-Mediated regulation of vascular smooth muscle cell phenotype.

Bioactive materials·2026
Same journal

Immunity-and-matrix-regulatory cells promote hyaline-like cartilage repair in osteoarthritis.

Bioactive materials·2026
Same journal

Injectable chondroitin sulfate-glycosylated decellularized extracellular matrix microgels activate Wnt/β-Catenin signaling to promote functional muscle regeneration in VML.

Bioactive materials·2026
See all related articles

Related Experiment Video

Updated: Oct 10, 2025

Accessing the Cytotoxicity and Cell Response to Biomaterials
09:46

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

3.9K

Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone.

David F Williams1

  • 1Wake Forest Institute of Regenerative Medicine, 391 Technology Way. Winston-Salem, North Carolina, 27101, USA.

Bioactive Materials
|December 13, 2021
PubMed
Summary
This summary is machine-generated.

Bioactive materials enhance biocompatibility through interfacial modifications. Scientific evidence supports mechanisms like bone induction and antimicrobial behavior, though clinical translation faces challenges.

Keywords:
BioactivityBiomaterialCell signalingHost responseMedical technology

More Related Videos

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

12.9K
Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
14:49

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Published on: April 15, 2022

5.3K

Related Experiment Videos

Last Updated: Oct 10, 2025

Accessing the Cytotoxicity and Cell Response to Biomaterials
09:46

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

3.9K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

12.9K
Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
14:49

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Published on: April 15, 2022

5.3K

Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Tissue Engineering

Background:

  • Bioactivity is crucial for biomaterial performance, influencing interactions with host tissue.
  • Understanding the interfacial region, termed 'the bioactivity zone,' is key to bioactivity phenomena.
  • Existing research demonstrates potential but highlights barriers to clinical translation.

Purpose of the Study:

  • To analyze scientific evidence underpinning bioactive materials.
  • To correlate bioactivity phenomena with biomaterial biocompatibility mechanisms.
  • To assess performance in bone induction, cell adhesion, immunomodulation, thrombogenicity, and antimicrobial behavior.

Main Methods:

  • Review of scientific literature on bioactive materials and biocompatibility.
  • Analysis of interfacial phenomena ('bioactivity zone') in biomaterials.
  • Examination of topographical/micromechanical and biologically active species effects.

Main Results:

  • Bioactivity is modulated by the material's interfacial region and local host tissue.
  • Topographical/micromechanical effects include osteoblast-osteoclast balance modulation and nanotopographical cell adhesion regulation.
  • Biologically active species, like metal ions and peptides, influence signaling pathways and cell attachment.

Conclusions:

  • Solid scientific evidence supports bioactivity mechanisms in specific biomaterials.
  • Material modification can be designed to specifically induce desired bioactivity.
  • Further research is needed to overcome clinical translation barriers for bioactive materials.