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Blood Routine Test Parameters Score, a Novel Predictor of Adverse Outcomes of Coronary Artery Disease Patients with
Jian Zhang1, Ying-Ying Zheng1,2,3, Ting-Ting Wu1
1Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Xinshi District, Urumqi 830011 P. R. China.
Insights
A new blood routine test parameters (BRTP) score predicts mortality in coronary artery disease (CAD) patients post-percutaneous coronary intervention (PCI). The BRTP score is particularly valuable for patients with diabetes, indicating higher risks for adverse outcomes.
Area of Science:
- Cardiology
- Clinical Risk Stratification
- Biomarker Discovery
Background:
- Coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI) require effective risk prediction tools.
- Existing risk scores may not fully capture the prognostic information available from routine blood tests.
Purpose of the Study:
- To develop and validate a novel risk score, the blood routine test parameters (BRTP) score.
- To assess the BRTP score's ability to predict clinical outcomes, including mortality, in CAD patients post-PCI.
Main Methods:
- A cohort of 6049 CAD patients post-PCI was analyzed (CORFCHD-PCI registry, 2008-2016).
- Patients were stratified into diabetic and nondiabetic groups.
- The incidence of all-cause mortality (ACM) and cardiac mortality (CM) was compared between high (≥5) and low (<5) BRTP score groups over a mean follow-up of 35.9 months.
Main Results:
- The BRTP score independently predicted ACM and CM in both diabetic and nondiabetic patients.
- In diabetic patients, the BRTP score also predicted major adverse cardiovascular events (MACE) and major adverse cardiovascular and cerebrovascular events (MACCE).
- The BRTP score did not significantly predict MACE or MACCE in nondiabetic patients.
Conclusions:
- The BRTP score serves as a novel and independent predictor of mortality in CAD patients after PCI.
- The BRTP score demonstrates particular utility in identifying high-risk diabetic patients undergoing PCI.
Background:
In this study, we developed a novel risk score named the blood routine test parameters (BRTP) score to predict the clinical outcomes in coronary artery disease (CAD) patients who had undergone percutaneous coronary intervention (PCI).
Methods:
There were 6049 patients with CAD after PCI enrolled in CORFCHD-PCI from January 2008 to December 2016. We divided these patients into two groups according to diabetes (diabetic group, n = 3809, and nondiabetic group, n = 2240). During a follow-up time of 35.9 ± 22.6 months, we compared the incidences of all-cause mortality (ACM) and cardiac mortality (CM), which were assigned as the primary outcomes between patients with a high BRTP score (≥5 points) and those with a low BRTP score (<5 points).
Results:
We found that the BRTP score independently predicted the risk for ACM and CM in both diabetic patients [ACM, hazard risk (HR) = 1.748 (95% confidence interval (CI): 1.186-2.575), P = 0.005; CM, HR = 1.728 (95% CI: 1.120-2.667), P = 0.014] and nondiabetic patients [ACM, HR = 1.682 (95% CI: 1.208-2.340), P = 0.002; CM, HR = 1.718 (95% CI: 1.188-2.484), P = 0.004]. However, the BRTP score was found to be an independent predictor for major adverse cardiovascular event (MACE) and major adverse cardiovascular and cerebrovascular event (MACCE) in diabetic patients [MACE, HR = 1.366 (95% CI: 1.076-1.734), P = 0.010; MACCE, HR = 1.330 (95% CI: 1.035-1.710), P = 0.026] but not in nondiabetic patients [MACE, HR = 1.241 (95% CI: 0.994-1.549), P = 0.056; MACCE, HR = 1.238 (95% CI: 0.981-1.562), P = 0.072].
Conclusions:
This study suggests that the BRTP score is an independent and novel predictor of mortality in CAD patients who had undergone PCI, especially in patients with comorbidity of diabetes.
Trial Registration:
ChiCTR-ROC-16010153. Registered 14, December, 2016.
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