Related Experiment Video

Updated: Oct 10, 2025

Concomitant Isolation of Primary Astrocytes and Microglia for Protozoa Parasite Infection
09:34

Concomitant Isolation of Primary Astrocytes and Microglia for Protozoa Parasite Infection

Published on: March 18, 2020

7.9K

Fonsecaea associated cerebral phaeohyphomycosis in a post-COVID-19 patient: A first case report

Simin Laiq1, Mubarak Al Yaqoobi2, Maimuna Al Saadi1

  • 1Department of Histopathology, Directorate General of Khoula Hospital, Muscat, Oman.

Clinical Infection in Practice
|December 13, 2021
PubMed

Insights

Cerebral phaeohyphomycosis, a fungal brain infection, can occur after COVID-19. This case highlights a rare Fonsecaea infection in a diabetic patient post-COVID-19, emphasizing poor prognosis.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Neurology

Background:

  • Phaeohyphomycosis is a chronic fungal infection caused by dematiaceous fungi, typically affecting the skin.
  • Cerebral phaeohyphomycosis, a rare invasive form, affects the brain and carries a poor prognosis, even in immunocompetent individuals.
  • The COVID-19 pandemic has seen an increase in invasive fungal infections, potentially due to viral effects or treatments on the immune system.

Observation:

  • A case of cerebral phaeohyphomycosis caused by Fonsecaea was observed.
  • The patient was a recently diagnosed diabetic woman from Oman.
  • The patient presented six weeks after recovering from moderate COVID-19 pneumonia.

Findings:

  • This report details a rare instance of Fonsecaea-associated cerebral phaeohyphomycosis.
  • The infection occurred in a patient with recent COVID-19 and diabetes mellitus.
  • The case underscores the potential for invasive fungal infections in the post-COVID-19 period.

Implications:

  • This case highlights the importance of considering invasive fungal infections, like cerebral phaeohyphomycosis, in patients with recent COVID-19, especially those with comorbidities.
  • Early diagnosis and management are crucial for improving outcomes in cerebral phaeohyphomycosis.
  • Further research is needed to understand the link between COVID-19, immunosuppression, and invasive fungal infections.
Keywords:
Brain abscessCOVID-19Cerebral phaeohyphomycosisChromoblastomycosisDematiaceous fungiFonsecaeaPigmented fungiSARS-CoV-2

More Related Videos

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans11:07

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

12.9K
Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation10:04

Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation

Published on: January 12, 2016

9.4K

Related Concept Videos

Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
1.9K
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
45
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
679
Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
6.1K
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
46
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
920