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Related Concept Videos

Brain Imaging01:14

Brain Imaging

380
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
380

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Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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Resting-State Functional Magnetic Resonance Imaging of Interhemispheric Functional Connectivity in Experimental

Shiliang Huang1, Qiang Shen1,2, Lora Talley Watts3

  • 1Research Imaging Institute, UT Health San Antonio, San Antonio, Texas, USA.

Neurotrauma Reports
|December 13, 2021
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Summary

Resting-state functional MRI (rsfMRI) revealed disrupted interhemispheric connectivity after moderate traumatic brain injury (TBI) in rats. This disruption partially recovered over 14 days, correlating with behavioral improvements, suggesting rsfMRI as a recovery marker.

Keywords:
MRIanimal studiesbehaviorrecoverytraumatic brain injury

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Area of Science:

  • Neuroscience
  • Radiology
  • Biomedical Engineering

Background:

  • Traumatic brain injury (TBI) can cause significant functional deficits.
  • Understanding neural recovery mechanisms post-TBI is crucial for developing effective treatments.
  • Resting-state functional magnetic resonance imaging (rsfMRI) shows promise for assessing brain network changes.

Purpose of the Study:

  • To longitudinally investigate changes in interhemispheric functional connectivity (IFC) using rsfMRI after moderate TBI in a rat model.
  • To correlate rsfMRI findings with behavioral recovery and lesion characteristics.
  • To explore the potential of rsfMRI as a biomarker for TBI recovery.

Main Methods:

  • Non-invasive rsfMRI was employed to monitor IFC in rats up to 14 days post-moderate TBI.
  • Independent component analysis was used to analyze rsfMRI data of sensorimotor networks.
  • Correlations were performed between rsfMRI metrics, behavioral scores, and imaging data (lesion volume, T2, diffusion-weighted images).

Main Results:

  • Animals with TBI exhibited less localized and less bilateral rsfMRI patterns in sensorimotor networks compared to controls, indicating IFC disruption.
  • Over time, rsfMRI patterns showed increased bilateral symmetry, suggesting partial IFC recovery.
  • Disrupted and recovering IFC positively correlated with behavioral score changes.

Conclusions:

  • rsfMRI effectively detected widespread disruption and subsequent recovery of IFC in sensorimotor networks following TBI.
  • The observed functional changes correlate with behavioral outcomes, validating rsfMRI's utility.
  • rsfMRI serves as a valuable tool for probing brain reorganization and can potentially be used to stage TBI and monitor treatment efficacy.