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Updated: Oct 10, 2025

Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry
Published on: April 3, 2019
Ambient Mass Spectrometry Imaging of Small Molecules from Cells and Tissues
Jae Young Kim1, Heejin Lim2, Dae Won Moon3,4
1School of Electronic and Electrical Engineering, College of IT Engineering, Kyungpook National University, Daegu, Republic of Korea.
Abstract:
New methods to analyze cells and tissues in ambient condition without any harsh chemical fixation or physical freezing and drying are summarized in this report. The first approach, an atmospheric pressure mass spectrometry imaging method, is based on laser ablation in atmospheric pressure assisted by atmospheric plasma and nanomaterials such as nanoparticles and graphene to enhance laser ablation. The second one is based on secondary ion mass spectrometry (SIMS) imaging of live cells in solution capped with single-layer graphene to preserve intact and hydrated biological samples even under ultrahigh vacuum for SIMS bio-imaging in solution.
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