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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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NCCN Guidelines® Insights: Squamous Cell Skin Cancer, Version 1.2022.

Chrysalyne D Schmults1, Rachel Blitzblau2, Sumaira Z Aasi3

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The National Comprehensive Cancer Network (NCCN) updated guidelines for squamous cell skin cancer. Key updates include new surgical margin terminology and advances in topical treatments, immunotherapy, and radiation therapy.

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Area of Science:

  • Oncology
  • Dermatology

Background:

  • Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer.
  • The NCCN Guidelines provide essential recommendations for cSCC management.
  • Regular guideline updates are crucial for incorporating the latest evidence.

Purpose of the Study:

  • To summarize recent updates to the NCCN Guidelines for Squamous Cell Skin Cancer.
  • To highlight key changes in diagnostic and treatment recommendations.
  • To inform clinicians about advancements in cSCC care.

Main Methods:

  • Annual review of NCCN Guidelines by a multidisciplinary panel.
  • Inclusion of public and institutional comments and submissions.
  • Focus on specific updates in surgical terminology, topical prophylaxis, immunotherapy, and radiation therapy.

Main Results:

  • Introduction of new terminology for surgical margin assessment: peripheral and deep en face margin assessment.
  • Updated recommendations for topical prophylaxis strategies.
  • Recent advancements in immunotherapy for regional and metastatic cSCC.
  • Refined approaches to radiation therapy for cSCC treatment.

Conclusions:

  • The updated NCCN Guidelines offer refined strategies for cSCC diagnosis and management.
  • New surgical terminology enhances precision in treatment planning.
  • Recent advancements in immunotherapy and radiation therapy provide more effective options for advanced disease.